SOLIRIS Resource Library

Critical resources and information to support your practice

Your practice is busy and time demands are often great. The SOLIRIS® Resource Library has been created to meet your PNH clinical information needs, help you stay abreast of research advances in PNH, and assist with patient management.

Because some of the materials available in the SOLIRIS Resource Library will be sent to your office, and to make Library access as easy as possible, you will need to create a personal account.

We encourage you to check back often, using your email address as the login, for updates, new materials, and evolving clinical insights.

This section of the SOLIRIS Resource Library contains essential tools to manage and counsel your patients with PNH. We encourage you to browse through the following downloadable materials.

Registered Users New Users Enter your email address to access website materials: Sign Up to access website materials Email:

PNH Disease Materials Order a Preprinted Copy An Overview of Paroxysmal Nocturnal Hemoglobinuria (PNH): Recognizing and Diagnosing the Disease Brochure designed to address basic questions about PNH and help physicians recognize and diagnose the disease Diagnostic Challenges: Case Studies in PNH Casebook developed from the PNH experience of practitioners throughout the U.S. Cases represent a range of clinical scenarios related to PNH Flow Cytometry Tool Reference card summarizing when and how to screen for PNH SOLIRIS Treatment-Related Materials Order a Preprinted Copy SOLIRIS Dosing and Administration Quick Reference Reference card for administering SOLIRIS SOLIRIS Infusion Tip Sheet Tips for patients to prepare for their first SOLIRIS infusion SOLIRIS OneSource™ Treatment Support Brochure Brochure outlining OneSource access and treatment support services for patients SOLIRIS™ Guardian Program Safety Brochure Brochure outlining safety information about SOLIRIS SOLIRIS: A Patient's Guide to SOLIRIS Therapy Patient brochure that provides information on PNH and treatment with SOLIRIS SOLIRIS Patient Safety Information Card Wallet reference card for patients Patient Material Available in Spanish Order a Preprinted Copy SOLIRIS: A Patient's Guide to SOLIRIS Therapy Patient brochure that provides information on PNH and treatment with SOLIRIS SOLIRIS OneSource™ Treatment Support Brochure Brochure outlining OneSource access and treatment support services for patients OneSource Third-Party Support Materials Order a Preprinted Copy SOLIRIS Claims Appeal Letter Specific Diagnosis Classifications and Associated ICD-9 Codes — Hospital Outpatient and Drug Administration Coding Specific Diagnosis Classifications and Associated ICD-9 Codes — Office Drug and Drug Administration Coding Demonstrating Medical Necessity for Flow Cytometry Letter ICD-9 for Flow Cytometry Work-up Statement of Medical Need Letter Reimbursement Summary by Payor Sample CMS 1500 Form Sample UB04 Form

IMPORTANT SAFETY INFORMATION

The effect of withdrawal of anticoagulant therapy during SOLIRIS treatment has not been established. Therefore, treatment with SOLIRIS should not alter anticoagulant management.

SEE FULL PRESCRIBING INFORMATION FOR COMPLETE BOXED WARNING INCLUDING WARNINGS, PRECAUTIONS, AND ADVERSE REACTIONS.

The most frequent adverse events observed in clinical studies were headache, nasopharyngitis, back pain, nausea, fatigue, and cough.

Please see important safety information (including boxed warning) as well as the complete prescribing information.

• About PNH
  • Pathophysiology
  • The Role of Hemolysis
  • PNH Morbidity & Mortality
  • Presentation of PNH
  • Screening for PNH
  • Flow Cytometry in PNH Diagnosis
  • Therapeutic Options
  • PNH Registry
• About SOLIRIS®
  • Mechanism of Action
  • Efficacy
    • Impact on Hemolysis
    • Reduction in Anemia
    • Transfusion Reduction
    • SOLIRIS and Fatigue Reduction
    • SOLIRIS and Patient Quality of Life
    • Fewer Thrombotic Events
  • Safety
    • Vaccine Requirement
    • Long-Term Patient Safety
    • Discontinuation
  • Dosing and Administration
  • Side Effects
  • Adherence and Timely Dosing
• SOLIRIS OneSource™
  • Alexion Case Managers
  • Coverage Information
  • Reimbursement
  • Patient Assistance
  • Office Coding for SOLIRIS
  • Hospital Coding for SOLIRIS
  • Coding for Flow Cytometry
  • Ordering SOLIRIS
  • OneSource Materials
• SOLIRIS Resource
  Library
• Prescribing Information
• Safety Information