The LDH Tracker Tool

Understanding LDH

Knowing your level of LDH or lactate dehydrogenase, an enzyme found in red blood cells, is critical to managing your PNH because your LDH lab value is tied directly to the degree of hemolysis (red blood cell destruction) in your body. Other lab values can also help you and your doctor manage the signs and symptoms of PNH, but do not measure hemolysis, the underlying cause of your signs and symptoms. By measuring your LDH, your physician can determine the degree of hemolysis in your body. Knowing your beginning LDH and monitoring it over time will help you and your doctor keep better track of the progression of your PNH. It can also be used to help assess the risk for developing serious complications associated with PNH. Your LDH level can change from time to time. Remember, it can increase if you have an infection or if you are under stress.

How the LDH Tracker works

  1. At the very top of the grid, you will find a row labeled “Date.” Write in the date your blood was tested in the first empty box found in this row.
  2. The bottom row provides space for you to record your laboratory values. Write in your laboratory result in this row, making sure that it corresponds to the date in the top row.
  3. Find the number in the column on the far left that most closely matches your laboratory value. Record an “X” in the box next to that number. This should be in the same column where you recorded the date and laboratory value.
  4. Continue to record your results in order in the columns to the right of your first entry on the grid.

Click here to view and print your LDH Tracker





IMPORTANT SAFETY INFORMATION

WARNING: SERIOUS MENINGOCOCCAL INFECTIONS

Soliris increases the risk of meningococcal infections. Meningococcal infection may become rapidly life-threatening or fatal if not recognized and treated early

  • Vaccinate patients with a meningococcal vaccine at least 2 weeks prior to receiving the first dose of Soliris; revaccinate according to current medical guidelines for vaccine use
  • Monitor patients for early signs of meningococcal infections, evaluate immediately if infection is suspected, and treat with antibiotics if necessary

The effect of anticoagulant withdrawal during Soliris treatment has not been studied. Therefore, treatment with Soliris should not alter anticoagulant management.

Soliris is generally well tolerated. The most frequent adverse events observed in clinical studies were headache, a runny nose (nasopharyngitis), back pain, nausea, and tiredness (fatigue).

Please see full prescribing information for SOLIRIS, including boxed WARNING regarding serious meningitis.