What Are the Symptoms of PNH?

PNH symptoms can change over time, and are different from person to person. This list will help you identify some symptoms you might have. Don’t be shy! Let your healthcare team know how you’re feeling — it’s an important part of managing your PNH.

Signs and Symptoms of PNH

You may experience one or more of the symptoms listed above quite frequently or just occasionally. However, you may not immediately feel other potential complications, such as blood clots and vital organ damage.




IMPORTANT SAFETY INFORMATION

WARNING: SERIOUS MENINGOCOCCAL INFECTIONS

Soliris increases the risk of meningococcal infections. Meningococcal infection may become rapidly life-threatening or fatal if not recognized and treated early

  • Vaccinate patients with a meningococcal vaccine at least 2 weeks prior to receiving the first dose of Soliris; revaccinate according to current medical guidelines for vaccine use
  • Monitor patients for early signs of meningococcal infections, evaluate immediately if infection is suspected, and treat with antibiotics if necessary

The effect of anticoagulant withdrawal during Soliris treatment has not been studied. Therefore, treatment with Soliris should not alter anticoagulant management.

Soliris is generally well tolerated. The most frequent adverse events observed in clinical studies were headache, a runny nose (nasopharyngitis), back pain, nausea, and tiredness (fatigue).

Please see full prescribing information for SOLIRIS, including boxed WARNING regarding serious meningitis.

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