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Critical Resources and Information to Support Your Practice

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Brochures and Tools

Are There PNH Patients in Your Practice? Brochure A diagnostic tool to help physicians better diagnose PNH.

PNH Registry Brochure An informative brochure about the PNH Registry, and how physicians and patients can become part of the PNH Registry.

Understanding Soliris Therapy: A guide for patients with PNH—and their caregivers Patient brochure that provides information on PNH and treatment with Soliris.

Soliris OneSource™ Brochure Brochure outlining OneSource access and treatment support services for patients.

Soliris Patient Safety Information Card Wallet reference card for patients.

Symptom Assessment Card An evaluation tool to help you monitor your patients with PNH.

Understanding PNH: A guide for patients and their caregivers A brochure for patients and their caregivers that provides information about PNH.

Publications

Soliris Publications:

Brodsky RA, Young NS, Antonioli E, et al. Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria. Blood. 2008;111:1840-1847.

Hillmen P, Hall C, Marsh JCW, et al. Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2004;350:552-559.

Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006;355:1233-1243.

Hillmen P, Muus P, Duhrsen U, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria [published online ahead of print August 16, 2007]. Blood. 2007;110:4123-4128. doi:10.1182/blood-2007-06-095646.

Differential Diagnosis of PNH:

Abou Antoun S, El-Haddad B, Wehbe E, Schulz T. Lysis and thrombosis: manifestation of the same disease. Am J Hematol. 2008;83:505-507.

PNH and Renal Disease:

Clark DA, Butler SA, Braren V, Hartmann RC, Jenkins DE Jr. The kidneys in paroxysmal nocturnal hemoglobinuria. Blood. 1981;57:83-89.

PNH Review Articles:

Hill A, Richards SJ, Hillmen P. Recent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2007;137:181-192.

Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995;333:1253-1258.

Parker C, Omine M, Richards S, et al, for the International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709.

Peffault de Latour R, Mary JY, Salanoubat C, et al. Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories [published online ahead of print June 5, 2008]. Blood. doi:10.1182/blood-2008-01-133918.

PNH and Bone Marrow Disorders:

Maciejewski JP, Rivera C, Kook H, Dunn D, Young NS. Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones. Br J Haematol. 2001;115:1015-1022.