About Soliris®

Soliris is the first and only approved medication for the treatment of patients with PNH to reduce hemolysis

By blocking complement (one of your body’s defense systems), Soliris reduces hemolysis, the underlying cause of complications, and therefore improves symptoms and reduces the major health problems associated with PNH.1 In clinical trials, patients who received Soliris experienced the following benefits1,2:

  • Reduced chronic hemolysis in all patients — immediate and long term
  • Fewer blood clots (thrombotic events), as compared to the same time period prior to starting Soliris
  • Significant improvements in fatigue levels and overall quality of life
  • Significant reduction in the need for transfusions

In clinical trials, the majority of patients received concomitant anticoagulant therapy.1 The effect of anticoagulant withdrawal during Soliris treatment has not been studied.1





IMPORTANT SAFETY INFORMATION

WARNING: SERIOUS MENINGOCOCCAL INFECTIONS

Soliris increases the risk of meningococcal infections. Meningococcal infection may become rapidly life-threatening or fatal if not recognized and treated early

  • Vaccinate patients with a meningococcal vaccine at least 2 weeks prior to receiving the first dose of Soliris; revaccinate according to current medical guidelines for vaccine use
  • Monitor patients for early signs of meningococcal infections, evaluate immediately if infection is suspected, and treat with antibiotics if necessary

The effect of anticoagulant withdrawal during Soliris treatment has not been studied. Therefore, treatment with Soliris should not alter anticoagulant management.

Soliris is generally well tolerated. The most frequent adverse events observed in clinical studies were headache, a runny nose (nasopharyngitis), back pain, nausea, and tiredness (fatigue).

Please see full prescribing information for SOLIRIS, including boxed WARNING regarding serious meningitis.


References: 1. Soliris® [package insert]. Cheshire, CT: Alexion Pharmaceuticals Inc; 2009. 2. Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006;355:1233-1243.